This book on urologic ultrasound has proven to be beneficial to urologists in training and currently in practice, and is structured by organ system for the practice of urology in the outpatient/office setting. The second edition expands on current techniques and procedures, includes ultrasound images, and gives new information on the use of ultrasound for the diagnosis and management of male reproductive conditions. The updated edition also discusses ultrasound in the intraoperative setting, chapters on male reproduction, ultrasound protocols, and standards for urologic practices performing ultrasound.
Bolstered with detailed illustrations and contributions from experts in the field, Practical Urologic Ultrasound, Second Edition is an authoritative and practical reference for all urologists worldwide in their mission to provide excellence in patient care.
This comprehensive volume presents an approach based on cutting edge clinical science to the integration of healthy behaviors in clinical practice, using three major categories; healthy eating, active living, and mindfulness. Chapters are authored and edited by a select group of national and international experts in their respective fields who have developed these concepts for application in routine practice. All chapters are formatted to provide key learning points and summarized conclusions for easy reference. Topics include the DASH diet, plant based nutrition, the Mediterranean diet, beneficial herbs and spices, fitness, spirituality, meditation, healthy sleep, and disease prevention.
Nutrition, Fitness, and Mindfulness will be a useful guide for all clinicians and healthcare professionals encouraging patients to make more thoughtful and healthy lifestyle choices.
This book comprehensively covers chronic lung disease and cardiovascular disease and their influence on one another including the epidemiology, physiology, risk factors, pathophysiology, clinical features, diagnostic issues including laboratory and imaging tests, and therapeutic considerations. How the diseases specifically overlap is explored in detail, covering presentation, symptoms, clinical examination findings, diagnostic test results, as well as a number of important medication interactions. The cardiovascular considerations in this book will include left ventricular systolic and diastolic dysfunction, pulmonary hypertension and right ventricular disease, as well as cardiac arrhythmias. The book also addresses extra-cardiac cardiovascular comorbidities such as cerebrovascular disease and peripheral arterial disease. Each chapter includes detailed illustrations as well as useful pearls and best practices, making this an ideal reference for pulmonologists, cardiologists, and residents caring for patients with increased risk for these comorbidities.
This book is a comprehensive guide to the diagnosis and management of all stages of pulmonary embolism, starting with acute and ending with chronic thromboembolic pulmonary hypertension. Acute pulmonary embolism (PE) is responsible for 150-250,000 hospitalizations and 60-100,000 deaths each year in the United States, making it the third most common cause of cardiovascular death. Acute PE spans a wide spectrum of clinical outcomes mainly based on the right ventricle's (RV) capacity to tolerate strain. There have been many recent advances in the field of PE, including guidelines on classification and risk stratification, anticoagulation, as well as evolving areas in treatment options and follow up.The text begins with a review of the epidemiology and risk factors for PE. Chapters then delve into reviewing the decision pathways based on PE severity and treatment options, including the use of oral anticoagulation, systemic and catheter-directed thrombolysis, mechanical and surgical thrombectomy, and hemodynamic support with extracorporeal membrane oxygenation. The text then focuses on post-PE complications such as post-PE syndrome, chronic thromboembolic disease, and chronic thromboembolic pulmonary hypertension (CTEPH).This is an ideal guide for providers of lung health, including pulmonary and critical care physicians, cardiologists, thoracic and cardiovascular surgeons. Physician-trainees, physician assistants, nurses and respiratory therapists with interest in pulmonary disorders, cardiovascular disease, pulmonary embolism, critical care or pulmonary hypertension will also find great value in this comprehensive guide.
This book serves as the primary reference for precision medicine in the fields of pulmonary, critical care and sleep medicine by documenting principles written by experts in several aspects of precision medicine. It combines fundamental concepts of the field with state-of-the-art studies and how they translate into individual preventive, diagnostic and therapeutic plans. Precision medicine is focused on the integration of individual variability with disease prevention and treatment principles derived from population studies. This concept has risen to prominence in recent years in parallel with advances in genetics, molecular diagnostics and novel target-specific therapies. This fundamental shift in the approach to treatment has broad implications in how we prevent, diagnose and treat disease. Describing key concepts of precision medicine and relating these to pulmonary, critical care and sleep disorders is essential to educate relevant stakeholders and increase the impact of pulmonary precision medicine. The book is organized into seven sections: introduction; genetics; biomarkers; precise phenotyping; mobile health, wearables and telemedicine; precision therapeutics; and enabling widespread adoption of precision medicine. The chapters are organized with an introduction to the specific theme, followed by its basic concepts. They then delve into how these basic concepts relate to the larger theme of precision medicine, new precision medicine approaches to dealing with these problems, and key takeaway points. Liberally illustrated with images, figures, and tables, the text is thorough and intuitive for clinicians and researchers to learn the processes and applications of precision medicine. This is an ideal guide for clinicians to learn new precision medicine concepts in the fields of genetics, genomics, mobile health, and how they apply to their practice and their patients, as well as researchers seeking a basic understanding of precision medicine to assist in designing future research studies.
This book provides a comprehensive overview of the multisystem disease, cystic fibrosis, for both pediatric and adult patients. Written by experts in the field, the text outlines the progressive nature of CF as well as the impact of this autosomal recessive disease on the respiratory, gastrointestinal, endocrine, rheumatologic, and renal systems, as well as the patient's mental health. The book begins with a chapter describing the history of cystic fibrosis and how the face of this life-shortening disease has changed over the past several decades. The following chapters elucidate the pathophysiology of how cystic fibrosis impacts each organ system. Current management and therapeutics are detailed with step-by-step guidelines for clinicians. This book is unique in that it highlights the entire person, not just the respiratory system, with detailed inclusion of the patient perspectives throughout, informing practice standards and considerations. This is an ideal guide for pediatric and adult physicians who care for patients with cystic fibrosis, as well as respiratory therapists, physical therapists, nurses, nutritionists, and pharmacists who care for these patients.
Part I. Introduction
Cardiac Safety of Noncardiac Drugs: Historical Recollections
Raymond John Lipicky
Part II. Preclinical and Pharmacogenomic Cardiac Safety Evaluations
Molecular Physiology of Ion Channels That Control Cardiac Repolarization
Jeanne M. Nerbonne and Robert S. Kass
Cellular, Molecular, and Pharmacologic Mechanisms Underlying Drug-Induced Cardiac Arrhythmogenesis
hERG Assay, QT Liability, and Sudden Cardiac Death
Arthur M. Brown
Pharmacogenomics in Drug Development: When and How to Apply
Richard Judson and Arthur J. Moss
Part III. Clinical Methodologies and Technical Aspects of Assessing Cardiac Safety of Investigational Drugs: Focus on Cardiac Repolarization
/> Assessment of Ventricular Repolarization From Body-Surface ECGs in Humans
Jean-Philippe Couderc and Wojciech Zareba
ECG Acquisition and Signal Processing: 12-Lead ECG Acquisition
Justin L. Mortara
Digital 12-Lead Holter vs Standard Resting Supine Electrocardiogram for the Assessment of Drug-Induced QTc Prolongation: Assessment by Different Recording and Measurement Methods
Holter Monitoring for QT: The RR Bin Method in Depth
Fabio Badilini and Pierre Maison-Blanche
Part IV. Application of Electrocardiology in Clinical Research
Fundamentals of ECG Interpretation in Clinical Research and Cardiac Safety Assessment
Ihor Gussak, Robert Kleiman, and Jeffrey S. Litwin
Design and Conduct of the Thorough Phase I ECG Trial for New Bioactive Drugs
Use of ECGs in Support of Cardiac Safety in Phase II and III Clinical Trials
Martin P. Bedigian
Cardiac Arrhythmia Assessment in Phase IV Clinical Studies
Gerald A. Faich and Annette Stemhagen
Statistical Analysis Plans for ECG Data: Controlling the Intrinsic and Extrinsic Variability in QT Data
Alan S. Hollister and Timothy H Montague
Interpretation of Clinical ECG Data: Understanding the Risk From Non-Antiarrhythmic Drugs
Rashmi R. Shah
Part V. Regulatory Considerations
The FDA's Digital ECG Initiative and Its Impact on Clinical Trials
Barry D. Brown
Quality Control and Quality Assurance for Core ECG Laboratories
Amy M. Annand-Furlong
ECG Digital Communities and Electronic Reporting of Cardiac Safety Data: New Technologies for Reporting Digital ECG Data in Clinical Research Settings
Scott Grisanti and Robert Brown
This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.
This new edition is devoted to a broad array of topics involving the circadian variation in cardiovascular diseases, with focuses on hypertension, stroke, and coronary disease. The volume covers clinical and device research related to home and ambulatory BP monitoring, as there have been significant advances in technology since the publication of the previous edition. In addition, there is an increased focus on the applicability of home and ambulatory BP monitoring in drug development in all therapeutic arenas. The text features contributions from chapter authors from around the world and who have great expertise in cardiovascular medicine, therapeutics, clinical trials, and evidence-based medicine.Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, Third Edition is essential reading for a large audience, including those practicing cardiology and nephrology with a special focus in hypertension, geriatrics and internal medicine, clinical trialists, regulators in the US, Europe, and Japan, and physicians in training in cardiology, hypertension, pharmacology, nephrology and neurology.
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell-cell, cell-ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Now in a fully revised and updated second edition, written and editing by leading experts in the field, this comprehensive and practical text brings together the latest guidelines and recommendations on the benefits of exercise and physical activity in the management of diabetes and its complications, providing both the researcher and practitioner with evidence-based information that is both theoretically and clinically useful. Part one sets the stage by discussing the epidemiology and prevention of type 2 diabetes and the metabolic syndrome. The physiological effects of exercise in type 2 diabetes are covered in part two, covering molecular mechanisms, adiposity, sex differences, cardiovascular consequences and musculoskeletal changes. Part three addresses practical issues that are essential in order to safely engage patients with diabetes in exercise-related research protocols and clinical programs, including DPP and LOOK Ahead, nutrition, behavioral changes, and guidelines for exercise testing. The final section examines special considerations for exercise in people with diabetes, such as those with neuropathy, cardiac issues and peripheral artery disease. Taken together, Diabetes and Exercise, Second Edition brings together the latest information and thought leaders in the field to create a unique and useful text for all clinicians, researchers and therapists working to integrate physical activity into their management strategies for the increasing number of diabetic patients.
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.
Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.
It has been 5 years since publication of the first edition of Dr. Attarian's Clinical Handbook of Insomnia which at the time was the first significant cl- ical textbook dedicated to insomnia, an often overlooked but important me- cal problem. The book was very well received. There has now been sufficient new information on the subject to warrant a second expanded edition of this very useful volume. Then, as now, the approach is to emphasize the frequent biological causes of insomnia rather than to attribute it primarily to underlying psychological and emotional factors. This new edition is an impressive major effort, having been expanded from 14 to 23 chapters including an extensive revision and updating of previous chapters with new references and the ad- tion of many new authors. An entirely new section of the book deals with insomnia in special populations including teenagers, pregnancy, menopause, and the geriatric population. Other new topics include insomnia as enco- tered in primary care practice, the role of circadian rhythms, the contribution of sleep related movement disorders to insomnia, insomnia in pain disorders, and the interesting entity of paradoxical insomnia, in which there is a large d- crepancy between the objective and subjective estimation of quantity of sleep. This collection within a single volume of practical information concerning a common but often neglected disorder remains a very useful addition to the armamentarium of the general or specialty physician who wishes to properly address insomnia in an informed and responsible manner.
This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of "liquid biopsy" for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our "hand lens" to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field.
Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.
This book is a clinical guide to controversial and emerging topics in pulmonary hypertension. There are multiple challenges and unanswered questions encountered by clinicians that evaluate, diagnose and treat patients with suspected or confirmed pulmonary vascular disease. This book provides a deep dive into the diagnosis and therapeutics of pulmonary hypertension supported by the literature and balanced with personal clinical experience. Expert authors have chosen these specific topics to address issues where uncertainty and/or controversy exists as well as highlight areas that are just being incorporated into clinical practice. These topics include: exercise pulmonary hypertension, sickle cell disease and pulmonary hypertension, and sarcoid pulmonary hypertension, among many others. Chapters address the diagnostic and treatment dilemmas posed by these various clinical entities through literature review, sharing of expert opinion, and review of recent guidelines and their applicability to the multiple different nuanced presentations of pulmonary hypertension. This is an ideal guide for pulmonologists, cardiologists, and other specialty practitioners caring for patients with pulmonary hypertension.
This text provides a broad and current review of this field and will serve as a valuable resource for trainees, academic and community surgeons, and members of industry with an interest in LESS. Due to the novelty and complexity of these procedures, the book focuses on detailed descriptions as well as pertinent illustrations for various upper and lower tract urologic procedures. The development of novel minimally invasive and robotic technology for more comfortable performance of these demanding procedures is covered. A complete description of instrumentation, platforms, and optics developed specifically for LESS is another primary focus of this text. Finally, a description of outcomes and complications as well as comparative data defining the status of LESS in relation to other current minimally invasive techniques is offered.
Atlas of Laparoscopic and Robotic Single Site Surgery will provide a detailed summary of the current status of LESS that will help guide surgical decision making, encourage investigative efforts, and stimulate industry led technology development.
While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases.
This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function.
Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.
The past 30 years have seen the emergence of a growing desire worldwide that positive actions be taken to restore and protect the environment from the degrading effects of all forms of pollution - air, water, soil, and noise. Since pollution is a direct or indirect consequence of waste production, the seemingly idealistic demand for "zero discharge" can be construed as an unrealistic demand for zero waste. However, as long as waste continues to exist, we can only attempt to abate the subsequent pollution by converting it to a less noxious form. Three major questions usually arise when a particular type of pollution has been identi ed: (1) How serious is the pollution? (2) Is the technology to abate it available? and (3) Do the costs of abatement justify the degree of abatement achieved? This book is one of the volumes of the Handbook of Environmental Engineering series. The principal intention of this series is to help readers formulate answers to the last two questions above. The traditional approach of applying tried-and-true solutions to speci c pollution problems has been a major contributing factor to the success of environmental engineering, and has accounted in large measure for the establishment of a "methodology of pollution control. " However, the realization of the ever-increasing complexity and interrelated nature of current environmental problems renders it imperative that intelligent planning of pollution abatement systems be undertaken.
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
This second edition volume is a desktop reference guide on nutrition and its clinical implications for health and disease. Presented in a new softcover format and user-friendly style, it serves as a valuable resource of practical information on nutrition for physicians and other healthcare professionals in their daily practice. The book covers all important aspects of nutrition including basic nutritional principles, nutrition through the lifecycle and optimal nutrition patterns through all stages of development, and diet and its role in prevention, cause, and treatment of disease.Nutrition Guide for Physicians and Related Healthcare Professionals is thoroughly updated from its predecessor, Nutrition Guide for Physicians and provides a wide perspective of the impact that nutrition has upon medical practice and will be an indispensable resource for primary care physicians and other medical professionals.
The second edition of this text reviews the prevention, evaluation and management of complications arising from female pelvic surgery. As the field has advanced and now become its own recognized subspeciality offering Board Certification there is even more interest in this area. This edition provides more specific detail of potential complications of robotic female pelvic surgery, different categories of midurethral slings and specific transvaginal apical procedures. There are unique complications based on the specific mode of sling placement or apical repair and they are further subdivided in this text. Potential complications of both routine and specialized vaginal procedures such as transvaginal slings, cystocele and rectocele repairs, urethral diverticulectomy, and transvaginal mesh repairs are reviewed. The chapters are divided by procedure allowing the reader to easily find what they are looking for. Images and diagrams of methods of evaluation and repair of these complications are included.
The second edition of Complications of Female Incontinence and Pelvic Reconstructive Surgery should serve as a reference allowing the surgeon quick and ready access to information about the complications of female pelvic surgery procedures - including detail on how to prevent, identify and manage them.
Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ?